In Week 4, James Conner led the Arizona Cardinals' backfield with a strong performance, rushing for over 100 yards and a touchdown. Bijan Robinson and Tyler Allgeier split opportunities for the Atlanta Falcons, while Derrick Henry showcased his dominance for the Baltimore Ravens with a spectacular touchdown run.

Chuba Hubbard excelled for the Carolina Panthers, and D'Andre Swift had a breakout game for the Chicago Bears. Meanwhile, Jonathan Taylor's strong outing for the Indianapolis Colts was overshadowed by an injury concern.

As the season progresses, several teams face crucial matchups in Week 5, with fantasy implications for players like Alvin Kamara and Saquon Barkley. The running back landscape continues to evolve, with emerging talents and injury challenges shaping the fantasy landscape.