The NFL's Week 10 showcased a series of significant injuries impacting key players across various matchups. Notably, the Carolina Panthers faced the New York Giants in an overseas game, while the Atlanta Falcons dealt with a loss against the New Orleans Saints.

Injuries included Mike Hughes of the Atlanta Falcons, who sustained a neck injury, and Miles Sanders from the Carolina Panthers, who was carted off with an ankle/foot issue. The Jacksonville Jaguars also saw Tank Bigsby exit with an ankle injury, while Wanya Morris of the Kansas City Chiefs left with a knee problem. Additionally, Taliese Fuaga from the New Orleans Saints suffered a thigh injury.