Sean Payton's NFL career has faced challenges since his departure from the New Orleans Saints after the 2021 season. After a year away, he was traded to the Denver Broncos in 2023, but his partnership with quarterback Russell Wilson struggled. Now, Payton is working with rookie Bo Nix in the competitive AFC West.

The Saints, under Dennis Allen, have also had a tough time, with a record of 27-30 since 2022 and inconsistent quarterback play. As they prepare to face the Broncos, both teams are looking to stay relevant in the league.

Key matchups include Saints tight end Juwan Johnson against Broncos safety Brandon Jones, and Broncos offensive tackle Frank Crum facing Saints defensive end Cameron Jordan. The game promises to be a test for both teams, especially with injuries impacting the Saints' lineup.

The prediction leans towards the Broncos, given the Saints' current struggles and injuries, with a final score forecast of Broncos 24, Saints 15.