The Buffalo Bills are set to face the New York Jets in a crucial AFC East matchup on Monday Night Football during Week 6. The Jets are coming off a challenging week, having fired head coach Robert Saleh, while the Bills are struggling with injuries and have lost their last two games.

Betting odds show a slight edge for the Bills, with a majority of bets placed on them. However, the Jets are expected to put up a strong defensive performance at home, especially with the recent trend of low-scoring games between these rivals. The prediction leans towards a close game, with the Jets potentially winning 19-16.