The San Francisco 49ers face significant injury challenges as defensive tackle Javon Hargrave is set to undergo surgery for a partially torn triceps, likely sidelining him for the remainder of the 2024 season. Coach Kyle Shanahan expressed the impact of Hargrave's absence, noting his strong performance and potential this season.

Quarterback Brock Purdy is day-to-day with back soreness after an MRI came back clean, while running back Christian McCaffrey is seeking specialized treatment in Germany for his Achilles tendonitis. Tight end George Kittle might return to practice soon, providing a glimmer of hope amidst the injury woes.