The San Francisco 49ers face a tough challenge in Week 4 after losing their first three games, while the Patriots come to town as 10.5-point underdogs. With key players like Christian McCaffrey sidelined, it raises questions about their ability to cover the spread.

Meanwhile, the model predicts the New Orleans Saints to cover against the Atlanta Falcons, who have struggled offensively. The Pittsburgh Steelers are also favored to beat the Indianapolis Colts, thanks to their surprising offensive prowess.