Brock Purdy's recovery from a shoulder injury continues to hinder his participation in practice for the San Francisco 49ers, as he only managed a brief pass during Wednesday's session. Having missed a game against Green Bay, his availability for the upcoming matchup with Buffalo is uncertain.

In addition to Purdy, key players like Trent Williams and Nick Bosa are also sidelined due to injuries, impacting the team's overall performance. Christian McCaffrey is back on the field but is still working to regain his previous form after a lengthy absence.