The San Francisco 49ers faced a challenging game against the Buffalo Bills, suffering a 35-10 defeat in snowy conditions. The slippery field caused numerous issues for players, with both teams struggling to maintain their footing.

Despite the adverse weather, the running game thrived, showcasing the highest rate of significant runs this season. However, the 49ers' performance was notably impacted, leading to critical fumbles from key players like Kyle Juszczyk and Brock Purdy.