This afternoon, the San Francisco 49ers are set to clash with the Chicago Bears in a crucial matchup that could determine their playoff aspirations.

Isaac Guerendo will make his debut as the starting running back, facing a formidable Bears run defense ranked 10th in the league. The 49ers must find ways to exploit his speed against this tough opponent.

Defensively, the 49ers are challenged by a Bears coverage unit that ranks 8th in the league, which could expose their struggling wide receiver corps.

Additionally, the Niners' run defense has been a significant issue, currently ranked 29th, and they must improve to have any chance of success.

Winning the turnover battle is essential, as the 49ers have struggled with turnovers this season, particularly with Brock Purdy's interceptions. A victory is crucial to avoid a fourth consecutive loss.