The Tennessee Titans faced a disheartening 34-10 defeat against the Buffalo Bills, marking their worst start since 2015 at 1-5. Despite an early 10-0 lead, the Titans struggled in the second half, failing to score and allowing the Bills to dominate.

First-year coach Brian Callahan expressed frustration over the team's inability to maintain performance, particularly in the second half, where they were outscored significantly. Quarterback Mason Rudolph, filling in for the injured Will Levis, had a rocky outing with turnovers and a lack of offensive production.