The Detroit Lions faced significant injury challenges during their matchup against the Arizona Cardinals, impacting key players like Derrick Barnes and Sam LaPorta.

Barnes was carted off with a knee injury and did not return. LaPorta, initially injured during a trick play, briefly re-entered the game before leaving again with a low-ankle sprain. Head coach Dan Campbell expressed cautious optimism about their recoveries, highlighting the importance of the upcoming bye week for healing.