The Los Angeles Rams face off against the Arizona Cardinals in a critical matchup both teams enter with losses. The Rams are looking to bounce back from a close defeat against the Lions, while the Cardinals hope to improve their performance after a loss to the Bills.

Key players include Rams wide receiver Cooper Kupp, who impressed in the opener, and Arizona's rookie Marvin Harrison Jr., who will need to step up after a quiet debut. Quarterback Matthew Stafford will be pivotal against the Cardinals' pass rush.