The Arizona Cardinals and New York Giants have weak run defenses that should be targeted in fantasy football. Identifying exploitable NFL run defenses is crucial for roster decisions.

Arizona's interior personnel groupings are weak, with key players like Justin Jones and Roy Lopez having glaring weaknesses. The Giants' defensive line starters also have deficiencies, making them vulnerable to opposing rushing attacks.

Get ahead in your fantasy football league by targeting these defenses for potential points against in 2024!