As the NFL season winds down, the San Francisco 49ers and Arizona Cardinals prepare for a matchup that holds little playoff significance but plenty of personal stakes. Both teams have faced a challenging season, with injuries and inconsistent performances leading to their elimination from postseason contention. With the 49ers sitting at 6-10 and the Cardinals at 7-9, this game represents a chance for younger players to showcase their skills and build momentum heading into the offseason.

49ers coach Kyle Shanahan highlighted the extensive injury list affecting his team, naming 13 players who were either out or limited in practice. Meanwhile, Cardinals quarterback Kyler Murray emphasized the importance of ending the season on a positive note, expressing a desire to carry good vibes into the offseason.

In a notable change, quarterback Joshua Dobbs will start for San Francisco, taking over for Brock Purdy. Dobbs previously played for Arizona and has a mixed record as a starter. On the other side, Cardinals running back Michael Carter is set to take on a larger role due to James Conner's injury, while tight end Trey McBride aims to break the NFL record for receptions by a tight end in a season. Rookie receiver Ricky Pearsall of the 49ers is also looking to conclude a challenging year on a high note after a standout performance last week.