Darius Robinson, the first-round pick for the Cardinals, will be sidelined for at least four games due to a calf injury and has been placed on injured reserve.
Christian Jones has a chance at returning after an ankle injury, while Tony Jones will not be available for activation due to NFL rules.
The Cardinals also released quarterback Desmond Ridder, leaving Clayton Tune as the backup for Kyler Murray.
Additionally, several players were waived as the team finalized its roster.