The Arizona Cardinals are 7.5-point road underdogs against the division-rival 49ers after a rough 42-14 loss to Washington. Despite a sporadic start to the season, including a close game against the Lions and a blowout win over the Rams, the AI PickBot predicts the Cardinals will cover the spread, projecting a loss by just three points on average. San Francisco, coming off a win over New England, has struggled to cover the spread, doing so only twice in their last eight games.