The Buffalo Bills face significant challenges early in the season, losing five key defensive players, including the suspended Von Miller and several injured starters. Linebacker Matt Milano is out until December, while safety Taylor Rapp is in concussion protocol, making him unlikely for the upcoming game against the Houston Texans.

Despite these setbacks, head coach Sean McDermott emphasizes the need for players to step up. Rookie Javon Solomon, who excelled in college, is expected to fill Miller's role. Young linebackers and backup players are also stepping into starting positions as the team adopts a next-man-up mentality.