The Buffalo Bills faced injury setbacks during their game against the Detroit Lions, with rookie safety Cole Bishop and veteran linebacker Matt Milano both leaving the field in the fourth quarter.

Bishop suffered cramping in his lower leg and was carted off, while Milano exited due to a groin issue. Baylon Spector stepped in for Milano, marking his return after being on injured reserve.

Despite these challenges, the Bills managed to secure a 48-42 victory, halting the Lions' 11-game win streak.