The Detroit Lions faced a tough challenge against the Buffalo Bills, ultimately losing 48-42 and ending their 11-game winning streak. Despite a historic performance from quarterback Jared Goff, who threw for 494 yards and five touchdowns, the Lions' defense struggled to contain Buffalo's offense.

Amon-Ra St. Brown had a standout game with 193 receiving yards, while the Lions' run game was largely ineffective. The team now must regroup as they prepare for a divisional matchup ahead.