The Chicago Bears faced a disheartening defeat against the San Francisco 49ers, losing 38-13 in their first game after firing head coach Matt Eberflus. Interim coach Thomas Brown expressed disappointment, stating, 'We got our butts kicked.'

Chicago struggled offensively, gaining only 88 yards and allowing rookie quarterback Caleb Williams to be sacked seven times. The defense was equally ineffective, conceding 452 yards and failing to contain San Francisco's explosive plays.