The Tennessee Titans face the Indianapolis Colts with several key players sidelined, including running back Tony Pollard and wide receiver Nick Westbrook-Ikhine. Tyjae Spears could step up as a viable RB2, while tight end Chigoziem Okonkwo is also expected to see increased targets.

In New Orleans, Alvin Kamara's groin injury may sideline him for Week 16, making Kendre Miller a must-add player. Meanwhile, the Baltimore Ravens have Rashod Bateman listed as questionable for their game against the Pittsburgh Steelers.

San Francisco's Isaac Guerendo is unlikely to play due to injury, opening the door for Patrick Taylor Jr. to start against the Miami Dolphins. Tee Higgins of the Cincinnati Bengals is also dealing with a knee issue, which could impact his availability against the Cleveland Browns.