The Cleveland Browns faced a catastrophic defeat against the New York Giants in Week 3, marking a severe setback despite the return of Jedrick Wills. The Giants' aggressive defense, led by Brian Burns, Dexter Lawrence, and Kayvon Thibodeaux, overwhelmed the Browns' offensive line, resulting in eight sacks and numerous pressures on quarterback Deshaun Watson.

Watson managed to throw for 196 yards and two touchdowns, but the overall offensive performance deteriorated significantly after a promising start. Key injuries on the offensive line further complicated matters, with Wyatt Teller and Wills both suffering knee injuries. The game unraveled for Cleveland as the Giants' quarterback, Daniel Jones, efficiently led his team to a strong first-half performance, leaving the Browns to grapple with decision-making blunders and turnovers in the closing stages.