Choosing the right players for a fantasy football lineup can be challenging, especially during the critical Week 1. Evaluating matchups relies heavily on previous performance statistics, which may not accurately represent current dynamics. The suggested rankings consider adjusted fantasy points allowed (Adj. FPA) to better assess weekly positional matchups.

Key players to start include Derek Carr of the New Orleans Saints, Jerome Ford of the Cleveland Browns, and Brandon Aiyuk of the San Francisco 49ers. Conversely, avoid starting Anthony Richardson of the Indianapolis Colts and Kyren Williams of the Los Angeles Rams, whose matchups lack favor.