The Thursday Pick Six newsletter previews the upcoming matchup between the Dallas Cowboys and New York Giants on 'Thursday Night Football.' This historic game marks the first Thursday night road game for the Cowboys on short rest. Currently favored by 5.5 points, the Cowboys are desperate to reverse their two-game losing streak, while the Giants seek to leverage their past success against Dallas.

Key players like Dak Prescott are expected to shine against a depleted Giants defense. With injuries affecting the Giants' secondary, the Cowboys aim to dominate through the air, which Prescott excels at. In contrast, the Giants may exploit the Cowboys' struggles against the run to forge their path to victory.

The newsletter also highlights the trend of underdogs performing well this season, and predictions about when undefeated teams, including the Buffalo Bills and Kansas City Chiefs, might face their first defeats.