The Denver Broncos face a challenging matchup against the Tampa Bay Buccaneers, particularly due to their struggles in Florida. Key areas of concern include the Broncos' offensive line, which has shown vulnerability in both pass and run-blocking situations. Communication issues and defensive strategies from opponents have further complicated their performance.

On defense, the Broncos will need to effectively handle the Bucs' explosive wide receiver group, including critical matchups involving Patrick Surtain II and Mike Evans. Success in these areas will be essential for Denver's chances of an upset against Tampa Bay.