The Detroit Lions faced a devastating blow during their 48-42 loss to the Buffalo Bills, losing three key defensive players to injuries that are likely to end their seasons.

Cornerback Khalil Dorsey was carted off the field after a serious ankle injury, while starting defensive tackle Alim McNeill and cornerback Carlton Davis III were also ruled out for the remainder of the year due to knee and jaw injuries, respectively. Coach Dan Campbell expressed concern about their recoveries.