The Seattle Seahawks, with an impressive 3-0 record, are set to take on the Detroit Lions, who stand at 2-1, in an exciting Week 4 Monday Night Football matchup. Both teams are grappling with significant injuries that could influence the game's outcome.

Betting odds favor the Lions slightly, reflecting public interest, though the total points are leaning towards the UNDER due to the injuries affecting both squads. With key players missing, especially Lions' center Frank Ragnow, the game promises to be a defensive battle.

Ultimately, the prediction leans towards a close game, with a final score of 23-20 in favor of the Lions.