The Detroit Lions faced a tough defeat against the Buffalo Bills, losing 48-42 in a high-scoring affair. Despite a strong offensive showing, the Lions' defense struggled to make crucial stops, allowing the Bills to take an early lead.

Quarterback Jared Goff led the Lions with an impressive performance, throwing for nearly 500 yards and five touchdowns. Amon-Ra St. Brown had a standout day, setting career highs in receptions and yards. However, the Lions' defense, particularly the linebackers, faltered against the Bills' offense.