San Francisco 49ers wide receiver Deebo Samuel Sr. is dealing with ongoing ribs and wrist injuries as the team prepares for their matchup against the Arizona Cardinals. With the 49ers already eliminated from playoff contention, quarterback Brock Purdy has been ruled out due to an elbow injury, leaving Joshua Dobbs to start in his place. Fantasy managers are advised to consider rookie receiver Ricky Pearsall as a WR3 option, especially if Samuel cannot play.

Pearsall has recently shown promise, finishing as the WR7 in PPR formats in Week 17. The Cardinals' weak pass defense could provide him with ample opportunities. Meanwhile, tight end George Kittle is also nursing injuries and may be rested to prevent further issues. If Kittle sits out, running back Isaac Guerendo and backup tight end Eric Saubert could see increased roles.

In Cincinnati, running back Chase Brown is a game-time decision due to a high-ankle sprain, with Khalil Herbert poised to take over if he cannot play. The Bengals have relied heavily on Brown this season, making Herbert's potential workload significant. Meanwhile, the Green Bay Packers are managing injuries to running backs Josh Jacobs and Chris Brooks, which could lead to increased carries for Emanuel Wilson as they face the Chicago Bears.

Lastly, the Philadelphia Eagles plan to rest key players, including wide receivers A.J. Brown and DeVonta Smith, as well as running back Saquon Barkley. This opens the door for Kenneth Gainwell and Will Shipley to step up in their matchup against the New York Giants, who struggle against the run.