In Week 5's matchup in London, the Minnesota Vikings defeated the New York Jets, but the game was marred by injuries. Running back Aaron Jones of the Vikings sustained a hip injury, while Jets quarterback Aaron Rodgers suffered a low ankle sprain. Cornerback Sauce Gardner was evaluated for a concussion but returned to the game.

Injuries were widespread across the league, affecting various teams and players, including the Bears, Bengals, Browns, Dolphins, Panthers, Ravens, Texans, and Vikings.