The Chicago Bears faced missed opportunities in their Week 3 game against the Indianapolis Colts, ultimately falling 21–9. A failed fourth-and-goal attempt and an unsuccessful Hail Mary pass were pivotal moments that contributed to their defeat.

Caleb Williams, the Bears' rookie quarterback, threw for 340 yards and connected with Rome Odunze for their first NFL touchdowns. Despite flashes of potential, Chicago's struggles highlighted their need for improved execution as they dropped to 1–2 on the season.