The Indianapolis Colts are preparing for a challenging matchup against the Detroit Lions after a victory over the New York Jets, where quarterback Anthony Richardson stood out. The Colts' defense faces a significant challenge against the Lions' potent offense, which features several key players.

Amon-Ra St. Brown, a top wide receiver, poses a threat with his impressive catch rate and yardage. The Colts' secondary must be vigilant to prevent him from making significant plays.

Additionally, tight end Sam LaPorta, despite dealing with a shoulder injury, remains a crucial target for quarterback Jared Goff. The Colts' linebackers and safeties must focus on limiting LaPorta's impact.

Running backs Jahmyr Gibbs and David Montgomery present another challenge, as the Colts struggle against the run. With the Lions' strong rushing attack, the Colts' defensive line must step up to prevent a dominating performance.