The Indianapolis Colts suffered their third consecutive defeat, losing 30-20 to the Buffalo Bills at Lucas Oil Stadium. Despite a promising performance from rookie AD Mitchell, who achieved 100% catch efficiency, the Colts' offense struggled significantly under Joe Flacco.

Defensively, E.J. Speed shone with his first career interception, while Kenny Moore II also had a standout game. However, head coach Shane Steichen faces scrutiny for his playcalling as the team's offensive struggles continue.