The Indianapolis Colts faced their 10th consecutive road loss against the Jacksonville Jaguars, falling 37-34. Despite the defeat, several players showed promise. Safety Nick Cross stood out defensively with 5 tackles and an interception, while wide receiver Alec Pierce made significant contributions with 134 receiving yards.

However, Michael Pittman Jr. struggled to make an impact, and defensive coordinator Gus Bradley faced criticism for the team's performance against Jaguars quarterback Trevor Lawrence, who excelled throughout the game.