The Indianapolis Colts are facing significant injury challenges ahead of their upcoming game against the Tennessee Titans. Key players including wide receivers Josh Downs and Michael Pittman Jr., as well as running backs Jonathan Taylor and Trey Sermon, missed practice due to various injuries.

Meanwhile, the Titans are optimistic about quarterback Will Levis starting after a successful practice. With the Colts struggling with injuries, particularly to their receiving corps, their chances of avoiding an 0-3 start in the AFC South are uncertain.