In the wake of Jonathan Taylor's ankle sprain, Indianapolis Colts running back Trey Sermon is poised to potentially start in Week 5 against the Jacksonville Jaguars. The Colts' signing of Trent Pennix suggests they may not rely on Taylor, increasing Sermon's chances for significant playtime.

Meanwhile, other players like Jeremy McNichols and Zach Charbonnet face their own challenges, with McNichols coming off a strong performance but still being advised to sit, while Charbonnet's value hinges on Kenneth Walker III's availability.