Patrick Mahomes led the Kansas City Chiefs to a 21-7 victory over the Cleveland Browns, throwing two touchdown passes before leaving the game with an ankle injury. The Chiefs built a commanding 21-0 lead, capitalizing on the Browns' six turnovers, including three interceptions from Jameis Winston.

Cleveland struggled offensively, with Jerome Ford's 62-yard touchdown run being a rare highlight. The game also saw star defensive end Myles Garrett leave briefly due to an eye injury but return to finish the match.