Christian McCaffrey's season with the San Francisco 49ers may be in jeopardy following a non-contact knee injury sustained during a loss to the Buffalo Bills. Head coach Kyle Shanahan indicated it could be a season-ending PCL injury, although further details are pending.

McCaffrey had previously missed significant time this season due to other injuries and had only played four games. His absence adds to the 49ers' growing injury list as they struggle with a 5-7 record, while the Bills continue to thrive at 10-2.