Julius Chestnut of the Tennessee Titans may step into a lead role due to injuries to Tony Pollard and Tyjae Spears, raising questions about his potential impact. Despite limited opportunities, he has performed well in preseason. However, his lack of experience makes him a risky fantasy option.

Meanwhile, D'Ernest Johnson's value diminishes with Tank Bigsby returning for the Jacksonville Jaguars. Joe Flacco is set to start for the Colts, making him a viable QB2 option. Other players like Nick Westbrook-Ikhine and Kimani Vidal also face uncertain fantasy outlooks.