The NFL's 'next man up' philosophy is crucial for fantasy football success, especially as injuries impact key players. Dak Prescott's season-ending injury is a significant setback for the Dallas Cowboys, while Trevor Lawrence's AC joint sprain could alter the Jacksonville Jaguars' offensive dynamics.

Justin Herbert emerges as a viable QB replacement, alongside Russell Wilson and Bo Nix, who are also making waves. Running backs like Audric Estime and Gus Edwards are gaining traction, while wide receivers like Quentin Johnston and Xavier Legette are stepping up.

Marquez Valdes-Scantling's standout performance for the New Orleans Saints highlights the importance of seizing opportunities in fantasy leagues. Tight ends like Will Dissly and Dawson Knox are also becoming valuable assets as the season progresses.