The San Francisco 49ers are facing challenges that many fantasy managers anticipated, despite the narrative of unforeseeable circumstances. Key players like Brock Purdy and Christian McCaffrey have histories that suggest vulnerability to injuries and declines in performance.

In fantasy football, streamers like Quinnen Williams of the New York Jets and Christian Rozeboom of the Los Angeles Rams are highlighted, while players like Anfernee Jennings of the New England Patriots and Reed Blankenship of the Philadelphia Eagles are recommended as fades due to their recent performances and matchups.