The Miami Dolphins and San Francisco 49ers are set for a crucial Week 16 matchup, both teams struggling with a 6-8 record. The Dolphins' run game has faltered significantly, ranking 26th in the league, while the 49ers face challenges with injuries to key players like Christian McCaffrey and Brandon Aiyuk.

Tua Tagovailoa's recent performance has raised concerns, especially against a formidable 49ers defense led by Nick Bosa. Meanwhile, Brock Purdy's struggles in the passing game could hinder San Francisco's offensive effectiveness. Special teams play could also be a deciding factor, with both teams experiencing issues this season.

With playoff hopes dwindling, motivation will be key for both sides as they aim to secure a vital win.