This article provides a comprehensive analysis of NFL matchups for Week 16, focusing on fantasy football implications. It highlights key players to start and sit across various games, emphasizing the importance of making the right lineup decisions as fantasy playoffs approach.

Notable matchups include the Houston Texans facing the Kansas City Chiefs, where players like Xavier Worthy and Patrick Mahomes are spotlighted. The analysis extends to other games, including the Pittsburgh Steelers at Baltimore Ravens and the Philadelphia Eagles at Washington Commanders, offering insights into player performance trends and injury updates.