The New England Patriots will face the Buffalo Bills in Week 16 of the NFL, but they will be without starting safety Jabrill Peppers due to a hamstring injury. Other key players missing include quarterback Joe Milton III and cornerback Marcus Jones.

New England, with a struggling 3-11 record, is seen as a significant underdog against a formidable Bills offense led by MVP candidate Josh Allen. Rookie quarterback Drake Maye will be looking to make a mark in this challenging matchup.