The Los Angeles Rams have placed three key players—receiver Puka Nacua, guard Steve Avila, and offensive tackle Joe Noteboom—on injured reserve following a challenging season opener against Detroit.

Nacua will miss at least four games due to a knee injury re-aggravated in the first half. Avila has a sprained ligament in his knee, while Noteboom is dealing with an ankle sprain.

The Rams are now facing a depleted offensive line ahead of their upcoming game against Arizona.