Jonathan Taylor, the Indianapolis Colts' star running back, is facing uncertainty for Week 5 due to a mild high ankle sprain. After a surgery last season, he has struggled with injuries but has been performing well this year, averaging 17.4 half-point PPR fantasy points per game.

If Taylor is unable to play, Trey Sermon is expected to take on a larger role. Sermon has shown promise in limited opportunities and could be a strong RB2 option against the Jacksonville Jaguars, who have struggled against running backs this season.