Christian McCaffrey, the All-Pro running back for the San Francisco 49ers, is set to make his season debut after an eight-week recovery from Achilles tendinitis. He expressed the emotional toll of being sidelined, stating it helped him appreciate the game more. Coach Kyle Shanahan confirmed McCaffrey will be activated from injured reserve, barring any last-minute issues.

However, the 49ers face challenges with defensive end Nick Bosa listed as questionable due to a hip injury, and cornerback Charvarius Ward is absent following a personal tragedy. McCaffrey's return is crucial as the team seeks to improve its offensive performance, which has struggled this season.