The San Francisco 49ers will face the New York Jets in their season opener without star running back Christian McCaffrey, who is sidelined due to a calf injury.

McCaffrey's absence is significant as he was a standout performer last season, leading in rushing yards and total touchdowns.

With McCaffrey out, the 49ers will rely on backup Jordan Mason and rookie Isaac Guerendo. The team also has several other players inactive for this matchup.