The San Francisco 49ers started strong but are facing challenges after recent losses and injuries. Key players like Christian McCaffrey and Elijah Mitchell won't play against the New England Patriots.
Despite losing to the Jets, the Patriots previously upset the Cincinnati Bengals. San Francisco is still a significant favorite in the upcoming matchup.
SportsLine's AI has generated predictions for Week 4, including a recommendation for the Jacksonville Jaguars to cover against the Houston Texans.
