The Chicago Bears and San Francisco 49ers, both struggling this season, are set to face off as the Bears seek to end a six-game losing streak under interim coach Thomas Brown. The Bears recently fired coach Matt Eberflus, hoping for a fresh start.

Meanwhile, the 49ers, once Super Bowl favorites, have suffered key injuries, including to star running back Christian McCaffrey, and are now at the bottom of the NFC West. Both teams are desperate for a turnaround as they head into this crucial matchup.